Protein Flexibility (1): FIRST and NMA Basics
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چکیده
Normal mode analysis (NMA) is a standard technique for studying the dynamics of biological systems. It provides an analytic description of the dynamics in a macromolecular system near a minimum by using a harmonic approximation of the potential. NMA can be applied in the analysis of protein flexibility. It has been shown that over half of the 3800 Yale protein movements can be modelled in a structure using at most two low-frequency normal modes [3].
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